| 摘要 |
A method is provided for preparing compounds of the formulae <IMAGE> <IMAGE> <IMAGE> <IMAGE> wherein A may be -C=C- or -C 3BOND C-, by reducing an epoxy lactone of the structure <IMAGE> to form the corresponding epoxy hemiacetal, reacting the epoxy hemiacetal with a silyl compound to form an epoxy silyl acetal, reacting the epoxy silyl acetal with an acetylenic derivative to form a silyl acetal, removing the silyl protecting group to form a hemiacetal, reacting the hemiacetal compound with an appropriate Wittig reagent to form a protected difluoro PGF2 alpha type compound, removing the protecting group, reacting the difluoro PGF2 alpha with an iodine compound to form an iodoether and reacting the iodoether with a base to form the desired compounds. Novel intermediates produced in the above method are also provided.
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