| 摘要 |
<p>PURPOSE:To obtain the titled compound as a beta-sympatholytic agent simply in high purity and in high yield, by reacting an epoxy compound such as glucidopropylamide, etc. as a raw mateial with 4-hydroxyinodole, followed by reducing the reaction product. CONSTITUTION:An epoxy compound (e.g., glycidamide, etc.) shown by the formulaI(R is H or lower alkyl) as a raw mateial is reacted with 4-hydroxyindole shown by the formula II, to give a 4-hydroxyindole derivative shown by the formula III, which is reduced, to give a 4-hydroxyindole derivative shown by the formula IV. The reduction, for example, is carried out in the presence of a catalyst such as lithium aluminum hydride, etc. The first reaction is done at normal temperature -60 deg.C, preferably at 30-50 deg.C, and the reduction is carried out at 0-50 deg.C, preferably 10-30 deg.C.</p> |
