| 摘要 |
<p>NEW MATERIAL:The gamma-aminobutyric acid ester derivative of formulaI[n is 0-3; R1-R5 are H or OH group protected with tetrahydropyranyl group, etc.; A is group of formula II (R is H or tetrahydropyranoxy), formula III, formula IV, etc. bonded through the nitrogen atom of amino or imino group; B is imino- protecting group such as t-butoxycarbonyl group]. EXAMPLE:alpha-Tetrahydropyranoxy-gamma-tetrahydrofuranoaminobutyric acid benzyl ester. USE:Intermediate for the synthesis of mugineic acids such as mugineic acid, 2'- deoxymugineic acid, avenic acid, etc. PROCESS:The gamma-aminobutyric acid ester of formulaIIis prepared by the reductive amination of the aldehyde of formula V with the amino compound or imino compound of formula VI, formula VII, formula VIII, etc. or their salts in a solvent such as methanol using a reducing agent such as sodium cyanoborohydride, followed by coupling of the reaction product.</p> |
