摘要 |
1. Claims for the contracting States : BE, CH, DE, FR, GB, IT, LI, NL, SE 3,4-Disubstituted 1,2,5-oxadiazole-2-oxides of the formula I see diagramm : EP0054873,P10,F11 wherein one of the radicals R**1 and R**2 denotes -CH3 and the other denotes -CONHR**3 N(R**4 )2 , see diagramm : EP0054873,P10,F13 see diagramm : EP0054873,P10,F1 see diagramm : EP0054873,P10,F3 -CONHR**3 OR**6 , -CONHR**7 , -CONR**4 R**8 , see diagramm : EP0054873,P10,F5 see diagramm : EP0054873,P10,F6 wherein R**3 denotes an alkylene radical -Cn H2n -, wherein n = 2, 3 or 4, R**4 and R**8 denote -CH3 or - C2 H5 , R**5 denotes -OCH3 or -Cl, R**6 denotes -H or -CH3 , R**7 denotes alkyl having 1 to 4 atoms, cycloalkyl having 5 to 7 C atoms, allyl, or pyridyl methyl, and X denotes -(CH2 )2 -O-(CH2 )2 -, see diagramm : EP0054873,P10,F8 -CH2 CH2 CH2 CH2 - or -CH2 CH2 CH2 CH2 CH2 - and pharmacologically acceptable acid addition compounds thereof. 1. Claims for the contracting State : AT Process for the preparation of 3,4-disubstituted 1,2,5-oxadiazole-2-oxides of the formula I see diagramm : EP0054873,P11,F2 wherein one of the radicals R**1 and R**2 denotes -CH3 and the other denotes -CONHR**3 N(R**4 )2 , see diagramm : EP0054873,P11,F3 see diagramm : EP0054873,P11,F4 see diagramm : EP0054873,P11,F5 -CONHR**3 OR**6 , -CONHR**7 , -CONR**4 R**8 , see diagramm : EP0054873,P11,F7 see diagramm : EP0054873,P11,F8 wherein R**3 denotes an alkylene radical -Cn H2n -, wherein n = 2, 3 or 4, R**4 and R**8 denote -CH3 or -C2 H5 , R**5 denotes -OCH3 or -Cl, R**6 denotes -H or -CH3 , R**7 denotes alkyl having 1 to 4 C atoms, cycloalkyl having 5 to 7 C atoms, allyl, or pyridyl methyl, and X denotes -(CH2 )2 -O-(CH2 )2 -, see diagramm : EP0054873,P11,F11 -CH2 CH2 CH2 CH2 - or -CH2 CH2 CH2 CH2 CH2 - as well as pharmacologically acceptable acid addition compounds thereof, characterised in that for the preparation of compounds of the formula Ia see diagramm : EP0054873,P11,F11 a 3-methyl-1,2,5-oxadiazole-2-oxide-4-carboxylic acid ester of the formula II see diagramm : EP0054873,P12,F1 wherein R**9 denotes alkyl having 1 to 6 C atoms, is reacted with an amine HZ and the amine employed here is selected in such a way that the radical Z, together with the carbonyl group of the ester II, forms the radical R**1 , and the resulting compound is, if appropriate, converted into an acid addition compound or, if appropriate, for the preparation of the compounds of the formula Ib see diagramm : EP0054873,P12,F4 is heated to temperatures from 150 to 220 degrees C, preferably 180 to 200 degrees C, and the resulting compound is, if appropriate, converted into an acid addition compound. |