ALKYLCARBOPENEMS, THEIR PREPARATION, USE IN PHARMACEUTICAL COMPOSITIONS AND INTERMEDIATES

摘要

Alkylcarbapenems of the formula (I): (I) and salts and cleavable esters thereof wherein A is a C=CH-CH3 or CH-CH2-CH3 group and Y is a -S-CH2-CH2-, -S-CH=CH- or -SO-CH=CH-group excluding substantially pure biologically produced (5R,6R)-3- (2-acetamidoethylthio)-6-ethyl-7-oxo-1-azabicyclo ¢3.2.0!hept-2-ene -2- carboxylic acid and its salts are disclosed along with methods for their preparation. Compounds of the formula I and their salts and esters wherein Ais a CH-CH2-CH3 group are antibacterial agents. Compounds of the formula I and their salts and esters wherein A is a C=CH-CH3 group are chemical intermediates which also possess antibacterial activity.