摘要 |
Title compds. (I; R1 = R2 = H, Me; X = Br, Cl, F; Y = C1-4 alkyl, alkoxy, halogen, trifluoromethyl; n = 0-2), useful as antiinflammation agents, were prepd. by the hydrolysis of oxepin-alkanoyl halide obtained from the reaction of II and Lewis acid at room temp in the presence of solvent. Thus, 28.6g 4-(2-carboxybenzyloxy) phenylacetic acid was refluxed in 16 ml thionyl chloride, and cooled to 0-5≦̸C in 160 ml 1, 2-dichloroethane. 14.1 g Aluminium chloride was added in the mixed soln., stirred for 90 min to give 25.6 g 6, 11- dihydro-11-oxodibenz b, e oxepin-2-acetic acid.
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