| 摘要 |
There is described novel hindered amine salts of 6,7 dihalo-3,4-dihydro-3 -oxo-2-quinoxaline carboxylic acids of the formula I: …<CHEM>… wherein R and R<1> are independently halogen: R<2> is H, CH3, or C2H5; R<3>, when taken singly, is H, CH3, C2H4OH, CH2C6H5 or CH2COOC2H5; R<4>, when taken singly, is a hindered hydrocarbyl radical of the group consisting of cycloactyl, norbornyl. Ad and CHR<2>Ad wherein Ad is a 1-adamantyl, a 2-adamantyl, a 3-(4-homoiso) twistane or a tricycloundecane radical; and R<3> and R<4> when taken together with the nitrogen to which they are attached, form an adamantylspiropyrrolidine radical. The compounds are prepared by treatment of the free acid with the free base or a salt of the appropriate hindered amine. They are effective antiviral agents in mammels. |
