PREPARATION OF COENZYME Q10

摘要

PURPOSE:To prepare the titled substance useful as a pharmaceutical or feed additive, by culturing bacteria belonging to Protaminobacter methanolica and capable of producing the titled substance, and separating the objective substance from the bacterial cells. CONSTITUTION:Novel bacteria capable of producing coenzyme Q10 e.g. Protaminobacter methanolica BP-3 (FERM-P No.4893), Protaminobacter methanolica BP-11 (FERM-P No.4894), etc. are cultured in a medium containing carbon sources such as glucose, xylose, methanol, etc., nitrogen sources such as urea, nitrates, etc., and other inorganic components, and the cultured bacterial cells are separated from the medium. Coenzyme Q10 is extracted from the bacterial cell by conventional extraction technique such as ethanol extraction, etc., and fractionated and purified to obtain the objective substance.