| 摘要 |
New and pharmacologically useful 17-amino-16-hydroxy-steroids of the androstane and oestrane series are disclosed having the formula I: <IMAGE> I and pharmaceutically acceptable non-toxic acid addition salts thereof, wherein: R1=H or hydrocarbyl of one to six carbon atoms (preferably lower alkyl, such as methyl); R2=H or hydrocarbyl of one to six carbon atoms (preferably lower alkyl, such as methyl); R3=a free, esterified or etherified hydroxyl group; ring A inclusive carbon atoms 6 and 9 has one of the following configurations: <IMAGE> in which R4=a free, esterified or etherified hydroxyl group; R5=O or H(R7), wherein R7 is a free, esterified or etherified hydroxyl group; R6=H or methyl; and the dotted lines represent an optional double bond in 4,5- or 5,6-position; as well as the enantiomers and racemates of these steroids. The novel compounds have antiarrhythmic properties.
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