摘要 |
Process for mfg. beta hydroxy amino acid, e.g. DL serine, threonine, beta hydroxyvaline or beta hydroxyphenylalanine, on an industrial scale with hardly any side prods. is effected by adsorbing aziridine-2-carboxylic acids of formula (I) (R1= hydrogen or methyl, (un)substd. phenyl or pyridyl gp.; R2= methyl gp. or hydrogen; X=-CO2H, CO2M (M=alkali metal or alkali earth metal), -CO2R3 (R3=1-5C lower alkyl or aralkyl gp.) -CONH2 or -CN, but is not -CO2H or CO2M when both R1 and R2 are hydrogen) or its deriv. on strongly acidic cation exchange resin, pref. H type resin, and heating in the presence of water for 1-100 hr. at 40-120 deg.C, pref. 2-50 hr. at 50-100 deg.C. |