| 摘要 |
<p>Analgesic 1,2,3,4-tetrahydroisoquinolines of the formula (1) <CHEM> wherein R1 and R2 respectively are hydrogen, hydroxy or alkoxy of 1 to 4 carbon atoms, R3 and R4 respectively are hydrogen or alkyl of 1 to 4 carbon atoms, and R5 is hydroxy, nitro or <CHEM> wherein R6 and R7 respectively are hydrogen, alkyl of 1 to 4 carbon atoms or RCO- wherein R is hydrogen or alkyl of 1 to 4 carbon atoms; pharmaceutically acceptable addition salts thereof with non-toxic acids; analgesic compositions thereof in an inert, pharmaceutical carrier; and methods of preparation from corresponding R1, R2, R3 and R4-substituted tetrahydroisoquinolines.</p> |
