| 摘要 |
Six 1-phenylethanolamines (I; R2,R3 = H or C1-4 alkyl; A = C1-4 alkylenediradical; &thgr;=phenylacetyl, phenoxy, acetyl, phenylaminocarbonyl or C4-20 alkanoyl) useful as topical inflammation inhibitors at 20 μg-5 mg daily, were prepd. Thus, 4,3,5-(H2N)Cl2C6H2COCHOH2O was condenced with H2NCMe2CH2NHCO-CH2Ph and the product reduced by NaBH4 to give I (R2=R3=Me, A = CH2, &thgr;=COCH2PH), isolated as the dihydrochloride.
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