| 摘要 |
R1 = CN, NO2, CF3, Cl, Br, I, H, C1-4 alkyl; R2 = CN, NO2, CF3, Cl, Br, I; R3 = H, C1-4 alkyl; R4 = C1-4 alkyl; R5 = CF3, CHF2, CH2F; R6 = H, OH, halo, C1-4 alkyl, alkoxy, C1-10 arylalkoxy C1-15 acyloxy were prepd. by reacting amines II with acid or its reactive derivs. For example, 3,4-dichloro-(2-hydroxy-2-trifluoromethyl propionyl)-anilide was prepd. by treating 3,4-dichloroaniline with 2 hydroxy-2-trifluoro methyl propionic acid at 180oC for 3 hr. The final products exhibit an antiandrogenic effect.
|
