| 摘要 |
<p>NEW MATERIAL:A compound (syn isomer) of formulaI[R1 is H or lower alkyl; R2 is lower alkyl; Y is phthalidyl or a group of formula II (R3 is H or CH3; R4 is lower alkyl or lower lakoxyl)]and a pharmacologically acceptable acid addition salt thereof. EXAMPLE:Pivaloyloxymethyl 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-methoxymethyl-3- cephem-4-carboxylate. USE:An antimicrobial agent for oral administration, having good absorption from the digestive tracts, and capable of decomposing the ester part at the 4-positin rapidly in the living body to form the carboxylic acid type. PROCESS:A compound of formula III is reacted with a compound of formula IV (R5 is optionally protected NH2; R6 is optionally protected OH or lower alkoxyl) or a reactive derivative thereof, and if necessary the protecting groups are removed to give the compound of formulaI.</p> |
