3-O-DEMTHYLISTAMYCIN B DERIVATIVE

摘要

NEW MATERIAL:A compound shown by the formula (R is H, glycyl, or formimidoylglycyl group) and its acid addition salt. EXAMPLE:3-O-Demthyl-2''-N-formimidoylistamycin B. USE:An antibacterial agent effective against ''Pseudomonas aeruginosa'', resistant bacteria, etc. PROCESS:For example, a monocarbonate of istamycin Bo produced by ''Streptomyces tenjimariensis'' SS-939 is reacted in hydrobromic acid under heating, treated with ammonia water, and purified by column chromatography, to give 3-O-demthylistamycin Bo. After the amino group of this compound is protected with a tertiary butoxycarbonyl group and benzyloxycarbonyl group, this compound is decomposed with hydrogen, reacted with a benzylformimidate, and the protecting groups are removed to give a compound shown by the formula.