发明名称 |
FREMGANGSMAATE FOR FREMSTILLING AV 2-ARYL-PROPIONSYRER VED DIREKTE KOBLING UNDER ANVENDELSE AV ET BLANDET MAGNESIUMHALOGENIDKOMPLEKS |
摘要 |
Compounds of the formula aryl CH(CH3)COOMgX, in which aryl denotes 6-methoxy-2-naphthyl, 4-alkylphenyl or 4'-fluoro-4-biphenyl, and X denotes chlorine or bromine, and their etherates, are described. They are prepared by treating a solution of the corresponding arylmagnesium bromide with the solution of a complex of the formula CH3CH(Br)COOMgX in an aprotic solvent containing an ether. The compounds are important intermediates in the synthesis of known 2-arylpropionic acids of therapeutic importance.
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申请公布号 |
NO145435(C) |
申请公布日期 |
1982.03.24 |
申请号 |
NO19780000524 |
申请日期 |
1978.02.15 |
申请人 |
SYNTEX PHARMACEUTICALS INTERNATIONAL LTD, |
发明人 |
MATTHEWS, GARY J.,;ARNOLD, ROBERT A., |
分类号 |
C07B31/00;C07B37/04;C07C51/00;C07C51/353;C07C53/19;C07C57/30;C07C57/58;C07C59/64;C07C63/24;C07C65/24;C07C67/00;C07F3/02;(IPC1-7):C07C57/30 |
主分类号 |
C07B31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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