| 摘要 |
New derivatives of the istamycin B series of compounds are provided, which are 3-O-demethylistamycin BO, 3-O-demethylistamycin B and 3-O-demethyl-2''-N-formimidoylistamycin B represented generally by Formula I or specifically by Formulae Ia, Ib and Ic, respectively. Compound Ia is useful as an intermediate for the preparation of Compounds Ib and Ic and the latter two compounds exhibit a high antibacterial activity against a wide variety of Gram-positive and Gram-negative bacteria and are useful antibiotics. Also provided are processes for the preparation of the new derivatives starting from istamycin BO. |
