摘要 |
A new method of preparing 3-(2-hydroxy-2-arylethyl)-2-iminothiazolidines of the formula <CHEM> and acid addition salts thereof, wherein Ar is phenyl, halophenyl, nitrophenyl or (trifluormethyl)phenyl, by protonating a starting material of the formula <CHEM> wherein Ar is as defined above, R<1> is chloro or bromo and R<2> is lower alkyloxy, aryloxy or optionally substituted phenyl, or, R<1> and R<2> taken together, represent an -O-radical, and subsequently reacting the thus obtained protonated intermediate with thiourea, ammonium isothiocyanate or an alkali- or earth alkaline metal isothiocyanate. The compounds of formula I are used as starting materials in the preparation of anthelmintic 2,3,5,6-tetrahydro-6-arylimidazo[2,1-b]thiazoles, in particular tetramisole and levamisole. The starting materials of formula (II) are obtained by hydrolyzing the corresponding halides of the formula <CHEM> wherein R<1>, R<2>, and Ar are as defined in formula (II) and X is chloro, bromo, or iodo. The starting materials of formula (II) and the halides of formula (III) are novel compounds.
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