| 摘要 |
6 beta -acylaminopenicillin-1 beta -sulfoxides are epimerized to 6 alpha -acylaminopenicillin-1 beta -sulfoxides using triethylamine and chlorotrimethylsilane. The 6 alpha -acylaminopenicillin-1 beta -sulfoxides produced in this process are useful intermediates in the synthesis of 7 beta -acylamino-7 alpha -alkoxy-3-methyl 1-oxa beta -lactam acids, a class of 1-oxa beta -lactam antibiotics.
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