| 摘要 |
Title compds. (I; R = monocyclic, bicyclic, spirocyclic N heterocyclic, substituted by substituted aminoalkyl, and bonded through N) were prepd. Thus, 4-(3-hydroxypropyl)piperidine was converted to its hydrobromide, brominated with PBr3 and treated with NaN3 to give 4-(3-azidopropyl)piperidine, which was converted to its N-formyl deriv. 6-Aminopenicillanic acid was treated with N-Formyl-4-(3-azidopropyl)piperidine to give I R = 4-(3-azidopropyl)-1-piperidyl which was reduced with Pd/C to give I(R = 4-(3-aminopropyl)-1-piperidinyl. The latter compd. had a bactericidal ED50 Klebsiella pneumonia 0.04 μ g/ml.
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