| 摘要 |
NEW MATERIAL:A cyanoalkaneamidooxacephalosporin derivative shown by the furmula I (A is lower alkyl, lower alkenyl, lower alkynyl; B<1> is H, salt-forming atom, salt-forming group, physiologically hydrolyzable ester group). EXAMPLE:7beta-(2-Cyano-n-butyryl)amino-7alpha-methoxy-3-(1-methyl-5-te trazolyl) thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid acetoxymethyl ester(formula II. USE:An antimicrobial agent for oral administration or for injection. Effective for preventing and remedying infectious disease of urinary tract, infectious disease of inspiration, osteomyelitis, etc. PROCESS:A corresponding compound is subjected to an operation, e.g., introduction of B<1> group, introduction of an acyl group in the side chain, introduction of cyano group, etc., to give a compound shown by the formula I. |
