| 摘要 |
N-carbamoylpiperazines I(R1,R2 = H, lower alkyl; X = naphthyl, substituted phenyl with R3, R4 and R5; R3,R4,R5 = H, halo, lower alkyl, lower alkoxy, benzyloxy, acylamino), showing powerful β-adrenaline interception activity, were prepd. by carbamoylating one of N in piperazine ring with CH2-CH-CH2-O-X and the other N with cyanic acid salt or R1NCO or (R1)(R2)NC(O)NHNO2, or (R1)(R2)NCOY (Y = halo). Thus, piperazine and p-chloro phenylglycidyl ether were refluxed in methanol and extracted with benzene to give N,N'-bis-3-(4-chlorophenoxy)-2-hydroxypropyl piperazine (m.p. 193-6≦̸C).
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