摘要 |
<p>A live attenuated mumps virus vaccine is prepared by cultivating a wild mumps virus strain for 1-18 serial passages in a first living cell to attenuate the virus, and then cultivating the attenuated virus in a second living cell for at least one serial passage to propagate and adapt the virus to the cell. The cell is selected from embryonated hen's egg amnion, embryonated hen's egg chorio-allantoic membrane, chick embryo fibroblast and human diploid cell. Quail embryo fibroblast is also employed. The vaccine prepared has strong immunogenecity and is safe.</p> |