| 摘要 |
The invention relates to new condensed as-triazine derivatives of the general formula (I) <IMAGE> (I) wherein Z represents a buta-1,3-dienyl group or a group of the formula (a), (b), (c) or (d) <IMAGE> <IMAGE> R1 denotes a C1-10 alkyl group, an oxo group or a C6-10 aryl or C6-10 aryl-(C1-3 alkyl) group optionally substituted by one or more identical or different substituents selected from the group consisting of amino, nitro, C1-6 alkyl, C1-6 alkoxy, hydroxy and halogen, R2 stands for hydrogen, C1-10 alkyl or amino, R3 represents hydrogen, C1-10 alkyl or C6-10 aryl or C6-10 aryl-(C1-3 alkyl) optionally substituted by one or more identical or different substituents selected from the group consisting of nitro, amino, C1-6 alkyl, C1-6 alkoxy, hydroxy and halogen, X- denotes an anion, and n is 0 or 1, with the proviso that if n is O, R1 is other than an oxo group and R1' and R2' form together a double bond, and with the further provisos that if n is 1, R1 represents an oxo group and the symbols R1' and R2' are not present, and if Z is a buta-1,3-dienyl group and R1 denotes an oxo group, R3 is other than unsubstituted phenyl. The new compounds of the general formula (I) can be prepared by cyclizing the compounds of the general formula (II) or (V), wherein R1, Z, R3 and X- have the above defined meanings, R4 is a leaving group and R7 represents hydrogen or C1-10 alkyl. The new compounds of the general formula (I) possess a valuable antidepressant effect and can advantageously be used in the therapy. |
