Novel organic amide compounds which are N-[2-[(acylaminoacylamino or aminoacylamino)phenyl]-4-hydroxy-5-pyrimidinylcarbonyl]cephalosporin compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate cephalosporin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-2-[(acylaminoacylamino or aminoacylamino)phenyl]-4-hydroxy-5-pyrimidine carboxylic acid or (b) reacting the free amino acid 7-aminocephalosporanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[2-[(acylaminoacylamino or aminoacylamino)phenyl]-4-hydroxy-5-pyrimidinylcarbonyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.
申请公布号
US4311699(A)
申请公布日期
1982.01.19
申请号
US19800112656
申请日期
1980.01.31
申请人
HASKELL, THEODORE H.;MICH, THOMAS F.;SANCHEZ, JOSEPH P.;SCHWEISS, DIETRICH
发明人
HASKELL, THEODORE H.;MICH, THOMAS F.;SANCHEZ, JOSEPH P.;SCHWEISS, DIETRICH