| 摘要 |
PURPOSE:To prepare a novel amylase inhibitor AI-B capable of inhibiting only a pancreatic amylase specifically, by cultivating a microorganism belonging to the genus Streptomyces. CONSTITUTION:A microorganism, e.g. Streptomyces viridosporus No.297-A2 (FERM-P No.5405), belonging to the genus Streptomyces, and having the ability to produce an amylase inhibitor AI-B is inoculated into a nutrient culture medium and cultivated to obtain the amylase inhibitor AI-B, capable of inhibiting only a pancreatic amylase specifically, stable by the treatment at 37 deg.C for 1hr in the pH range of 5.5-10.0, and exhibiting the residual ativity >=80% by the treatment at 70 deg.C for 30min in a 0.1M phosphoric acid buffer solution (pH7.0) from the culture. |
