Aerosol compositions for the imaging, diagnosis and targetted therapy of inflamed and tumoral focuses.

摘要

The invention relates to an aerosol composition containing a carrier agent capable of recognising and binding to inflammatory and tumoral foci mobilising macrophages in close proximity to them, and an aerosol substrate, wherein the aforementioned carrier agent consists of a polysaccharide compound chosen from the compound D 25 extracted from the membrane proteoglycans of the Klebsiella pneumoniae bacterium and having a molecular weight of 30 +/- 10 kD, and the oxidised D 25 compound in which the galactofuranose residue (Galf) of the linear polysaccharide chain of D 25 has been converted to arabinose, and their amide, ester or ether type derivatives, as well as their quaternary ammonium derivatives and salts, and also the derivatives obtained by grafting of phosphatides.