PREPARATION OF 2-ARYL-PROPIONIC ACIDS BY DIRECT COUPLING UTILIZING A MIXED MAGNESIUM HALIDE COMPLEX

摘要

Intermediates useful in the preparation of 2-aryl-propionic acids having anti-inflammatory, antipyritic and anelgesic properties are disclosed. Such 2-aryl-propionic acids are prepared by the direct coupling of aryl magnesium bromides, where aryl may be 6-methoxy-2-naphthyl, 4-alkylpnenyl and 4'-fluoro-4-biphenyl with a complex of the formula CH3CH(Br) COOMgX, wherein X is chloro or bromo. The complex is prepared by treating a Grignard reagent with alpha-bromo-propionic acid.