SUBSTITUTED 2-CYCLOPROPYL-CHROMONES AND PROCESS FOR THEIR PREPARATION

摘要

The invention is compounds of the formula: (I) wherein n is zero or l; R1 is hydrogen or C1-C20 alkyl, unsubstituted or substituted by a C2-C5 alkanoyloxy or by a group, wherein each of R4 and R5 is independently selected from the group consisting of hydrogen and C1-C10 alkyl, or R4 and R5, taken together with the nitrogen atom form a N-pyrrolidinyl, piperidino or morpholino radical; R2 is C1-C8 alkyl or C3-C4 alkenyl; R3 is (a) furyl, thienyl or pyridyl, the furyl, thienyl and pyridyl groups being unsubstituted or substituted by a methyl group; or (b) the group wherein each of R6 and R7 is independently selected from the group consisting of (a') hydrogen; (b') halogen; and (c') the group -(O)n1 -R8, wherein n1 is zero or 1 and R8 is C3-C4 alkenyl or C1-C6 alkyl, the alkenyl and the alkyl groups being unsubstituted or substituted by one or more C1-C2 alkoxy or hydroxy groups. The invention also extends to physiologically acceptable salts of the compounds. The compounds display anti-allergic activity, as evidenced by the fact that they are active in the passive cutaneous anaphylaxis t?st in rats.