PROCESS FOR PRODUCING OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE COMPOUND

摘要

A process for producing an optically active 3-(2-nicotinoylaminoethyl)ester of (-)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid by asymmetrically hydrolyzing bis(2-nicotinoylaminoethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate or a salt thereof with an enzyme which can asymmetrically hydrolyze the carboxylate groups bonded to the 3- and 5-positions of a 1,4-dihydropyridine ring. The invention provides a process for producing a very important intermediate for producing only that optical isomer which is suitable as a medicine among the isomers of 3-(2-nicotinoylaminoethyl) 5-(3-nitroxypropyl) ester of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid.