发明名称 |
ALKOXI-ACYL-KARNITINER, FORFARANDE FOR DERAS FRAMSTELLNING OCH FARMACEUTISKA KOMPOSITIONER INNEHALLANDE DESAMMA |
摘要 |
A novel class of alkoxy-acyl carnitines, wherein the alkoxy-acyl radical has from 4 to 6 carbon atoms (tipically: methoxypropionyl, ethoxypropionyl and propoxyacetyl) is prepared by reacting a solution of a carnitine salt in an organic solvent with an alkoxy-acyl halogenide, thus obtaining the corresponding salt of alkoxy-acyl carnitine. By eluting an aqueous solution of this salt through a column of an ion exchange resin activated in Cl- or Br- form, the chloride or bromide of alkoxy-acyl carnitine is obtained. The alkoxy-acyl carnitines are therapeutically effective in the treatment of cardiac disorders, hyperlipidaemias and hyperlipoproteinaemias. |
申请公布号 |
SE8103368(L) |
申请公布日期 |
1981.12.01 |
申请号 |
SE19810003368 |
申请日期 |
1981.05.27 |
申请人 |
SIGMA TAU IND FARMACEUTI |
发明人 |
CAVAZZA C;DE WITT P;TINTI M O;QUARESIMA E |
分类号 |
C07C227/16;A61K;A61K31/14;A61K31/195;A61K31/205;A61K31/22;A61K31/24;A61K31/265;A61P9/00;A61P9/06;A61P25/02;C07C;C07C67/00;C07C227/00;C07C229/22;(IPC1-7):C07C101/30;A61K31/19 |
主分类号 |
C07C227/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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