PPAR ACTIVATOR DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS

摘要

The invention relates to compounds having formula (I), in which: A represents -(C=C)- or -(CH<SUB>2</SUB>)<SUB>m</SUB>-, wherein m is 1, 2 or 3; Y is a hydrogen atom or a hydroxyl radical or forms a double bond with X<SUB>1</SUB> or X<SUB>2</SUB>; X<SUB>1</SUB> and X<SUB>2</SUB> represent -(CH<SUB>2</SUB>)n-, wherein n is 0, 1, 2 or 3, or a (=CH-) group, on the condition that X<SUB>1</SUB> and X<SUB>2</SUB> do not simultaneously represent a (=CH-) group; R<SUB>1</SUB> and R<SUB>2</SUB> represent a linear or branched alkyl group with between 1 and 8 carbon atoms or an aryl radical, with the provision that, when A is -(CH<SUB>2</SUB>)<SUB>m</SUB>-, X<SUB>1</SUB>R<SUB>1</SUB> and X<SUB>2</SUB>R<SUB>2</SUB> each comprise at least 3 carbon atoms; Z represents an oxygen, a sulphur atom or -(CH<SUB>2</SUB>)-; and R<SUB>3</SUB>, R<SUB>4</SUB> and R<SUB>5</SUB> represent a hydrogen atom or a lower alkyl group with between 1 and 6 carbon atoms. The invention also relates to the use of said compounds in therapeutics for the treatment of certain hyperlipidemias and atherosclerosis.