WERKWIJZE VOOR HET BEREIDEN OF VERVAARDIGEN VAN EEN GE- NEESMIDDEL MET EEN ANTICONVULSIEVE WERKING, ALSMEDE WERKWIJZE VOOR HET BEREIDEN VAN DAARVOOR GESCHIKTE 1-ARYLCARBONYL-2-(1H-1,2,4-TRIAZOL-1-YL)BENZEENDERIVA- TEN.

摘要

Triazolyl ketone derivatives of the formula: <IMAGE> (wherein R represents lower alkoxy or the group <IMAGE> R4 and R5 each represents hydrogen, lower alkyl, <IMAGE> represents hetero ring selected from pyrrolidino, piperidino, and morpholino; R1 represents halogen or nitro; R2 represents hydrogen or lower alkyl; R3 represents lower alkyl, phenyl, or the group <IMAGE> R6 represents hydrogen, lower alkyl, or benzyl; R7 and R8 each represents hydrogen, lower alkyl, or <IMAGE> represents hetero ring selected from pyrrolidino, piperidino, and morpholino; and Ar represents phenyl, o-halogenophenyl, or 2-pyridyl) and their pharmaceutically acceptable acid addition salts, being useful as anxiolytics, hypnotics, anticonvulsants, muscle relaxants, or their synthetic intermediates, are prepared by several routes.