摘要 |
<p>Compounds having the general formula (I> <IMAGE> wherein: Z is -CN; -CONH2 or -COOR1, wherein R1 is hydrogen, C1-C6 alkyl or a carboxy-protecting group; A1 is a bond or has any of the meanings given below for A; in which case it can be the same as A or different therefrom, A is a branched or straight chain C1-C6 saturated or C2-C6 unsaturated aliphatic hydrocarbon radical, which may be unsubstituted or substituted by one or more substituents selected from hydroxy, halogen, cyano, amino, -COR', where R' is hydrogen or C1-C6 alkyl, or -COOR1, wherein R1 is as defined above; R is hydrogen; a hydroxy-protecting group or a branched or straight chain C1-C6 saturated or C2-C6 unsaturated aliphatic hydrocarbon group, which may be unsubstituted or substituted by one or more substituents selected from a) hydroxy; b) cyano; c) C1-C6 alkyl; <IMAGE> wherein each of R2 and R3, which may be the same or different, is hydrogen, C1-C6 alkyl, C1-C6 aliphatic acyl or one of R2 and R3 is hydrogen and the other is an amino-protecting group; and e) -COOR1, wherein R1 is as defined above; Y is -O-COCH3 or -S-Het, wherein Het is an optionally substituted heterocyclic group T is a carboxy or esterified carboxy group; as well as the pharmaceutically and veterinarily acceptable salts thereof are useful antibacterial agents against gram-positive and gram-negative bacteria.</p> |