Compounds and method for coating surfaces of medical devices such as stents in a haemocompatible manner

摘要

The disclosure relates to oligo- and polysaccharides containing the sugar structural element N-acylglucosamine or N-acylgalactosamine, in addition to the use thereof for producing haemocompatible surfaces and to methods for coating surfaces in a haemocompatible manner with said oligo- and polysaccharides, which constitute the common biosynthetic precursor substances of heparin, heparan sulphates and chitosan. The disclosure also relates to methods for producing the oligo- and/or polysaccharides, in addition to diverse application options involving haemocompatible surfaces. The disclosure specifically relates to the use of the oligo- and/or polysaccharides on stents involving at least one haemocompatible coating that has been applied according to the disclosure and that contains an anti-proliferative, anti-inflammatory and/or athrombogenic active ingredient, to methods for producing said stents and to the use of the latter for preventing restenosis.