2`-AMINO-2`-DEOXY-2-SUBSTITUTED INOSINE AND ITS PREPARATION

摘要

NEW MATERIAL:The titled compound of formula I (X is lower alkyl or halogen). EXAMPLE:9-beta-D-2'-Amino-2'-deoxy-2-methylinosine. USE:An carcinostatic agent capable of suppressing the multiplication of Hela cells or P815 cancer cells. PROCESS:A 2-substituted hypoxanthine of formula X or a riboside thereof is reacted with 2'-amino-2'-deoxyuridine of formula III by the action of a microorganism of the genus Pseudomonas, Flavobacterium, Achromobacter or Salmonella, e.g. Klebsiella pneumoniae ATCC9621, to give the compound of formula I.