发明名称 |
NOVEL ATTENUATED DENGUE VIRUS STRAINS FOR VACCINE APPLICATION |
摘要 |
The present invention discloses a method of eliciting an immune response and a method of vaccination comprising administration of a mutated flavivirus. The mutated flavivirus comprises at least one mutation in a nucleic acid sequence encoding for the non-structural protein 5 of the flavivirus sequence resulting in inactivation of the 2′O-methyltransferase. |
申请公布号 |
EP2897628(A4) |
申请公布日期 |
2016.06.22 |
申请号 |
EP20130839125 |
申请日期 |
2013.09.23 |
申请人 |
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;NOVARTIS AG;BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY |
发明人 |
FINK, KATJA;SHI, PEI-YONG;QIN, CHENG FENG |
分类号 |
A61K35/76;A61P31/12;C12N15/40 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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