| 摘要 |
The use of cortisol-21-mesylate and dexamethasone-21-mesylate as inhibitors of glucocorticoid steroid hormone action is disclosed. These compounds were found to be irreversible inhibitors of glucocorticoid action, for example, in both whole and broken rat hepatoma tissue culture cells. The compounds contain both the basic glucocorticoid structure and a reactive functional group capable of yielding a covalent receptor-steroid complex.
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