Transdermal medication system for isosorbide dinitrate

摘要

A pharmaceutical preparation comprising: (a) isosorbide dinitrate as active ingredient (b) a solvent for isosorbide dinitrate (c) an ointment consistency agent (d) an emulsifying agent (e) water, and (f) possibly customary preservatives, antioxidants, buffers and/or odorants; where the weight ratio of water: consistency agent including emulsifying agent: solvent is 30 to 80: 3 to 35: 3 to 35, the amount of emulsifying agent is from 0% to 15% by weight and the amount of isosorbide dinitrate is from 2% to 20% by weight. The preparation has an ointment-like consistency and is administered topically to the skin, where it has a high adsorption rate and a long duration of response.