NB-QUATERNARY DERIVATIVES OF AJMALIN AND ISOAJMALIN, PROCESS AND INTERMEDIATE PRODUCTS FOR THE MANUFACTURE OF THE DERIVATIVES, THE PHARMACEUTICALS CONTAINING THE DERIVATIVES,AND THE USE OF THE DERIVATIVES

摘要

New quaternary derivatives of 10-bromoajmaline and 10-bromoisoajmaline are disclosed which exhibit antiarrhythmic and adrenolytic properties and which have the formula I (I) wherein R represents a carbon-attached organic group containing 1 to 10 carbon atoms and A- represents an acid anion as well as pharmaceutical formulations thereof and processes and intermediates for their preparation.