发明名称 |
NUCLEOSIDDERIVATE, IHRE HERSTELLUNG UND PHARMAZEUTISCHE MITTEL |
摘要 |
<p>New nucleoside derivatives possessing strong anti-tumor activity with low toxicity, represented by the general formula: <IMAGE> wherein (A-CO- is a residue of a saturated straight or branched chain fatty acid, B is a nitrogen-containing group, Q is a substituent of the fatty acid, Z and Z' each is H or OH with the proviso that both of Z and Z' are not OH, and n is zero or an integer of at least 1, as well as physiologically acceptable salts thereof. These nucleoside derivatives are prepared by introducing the nitrogen-containing acyl group directly in one step or indirectly in two steps into the 5'-position of 5-fluorouridine, 2'-deoxy-5-fluorouridine or 1- beta -D-arabinofuranosyl-5-fluorouracil and splitting off any protective group and optionally converting the free compound into a physiologically acceptable salt thereof or vice versa.</p> |
申请公布号 |
DE3044740(A1) |
申请公布日期 |
1981.09.24 |
申请号 |
DE19803044740 |
申请日期 |
1980.11.27 |
申请人 |
FUJI KAGAKU KOGYO K.K. |
发明人 |
ENDO,TAKESHI;SAKAI,KATSUMI;CHOU,KIYOAKI;INAMOTO,YOSHITAKA;TESHIGAWARA,HARUHIKO |
分类号 |
C07H19/06;(IPC1-7):07H19/08;61K31/70 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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