Process for producing pyridine derivatives having a trifluoromethyl group at beta -position thereof

摘要

Pyridine derivatives having a trifluoromethyl group at beta -position thereof are produced by reacting beta -picoline with chlorine and hydrogen fluoride in a vapor phase at high temperature for a short time. The reaction condition can be mild and the yield of the object compound is increased by reacting them in the presence of a specific metal fluodie. The pyridine derivatives useful as starting materials for agricultural chemicals and medicines can be continuously obtained by a simple reaction at high yield.