| 摘要 |
<p>The present invention as disclosed provides a process for the production of an aminocyclol of formula I, I wherein R1 is an amino protecting group or a lysergic acid residue; R2 is an alkyl group having 1 to 4 carbon atoms; R3 and R5 are each independently hydrogen or an alkyl group of 1 to 5 carbon atoms; and R4 is hydrogen, an alkyl group of 1 to 6 carbon atoms, phenyl, benzyl, or benzyl mono-substituted by an alkoxy group of 1 to 4 carbon atoms; which comprises intramolecularly cyclizing a compound of formula II, II wherein R1 to R5 are as defined above, and R6 is a leaving group. The compounds of formula I are intermediates for the production of ergot alkaloids such as dihydroergotamine and dihydroergonine.</p> |
