摘要 |
<p>The invention provides compounds of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="24" wi="78" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein each of R<Sub>1</Sub>, R<Sub>2</Sub> and R<Sub>3</Sub>, which can be the same or different is hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxv, amino, hydroxy or nitro; R<Sub>4</Sub> is hydrogen or alkyl of 1 to 7 carbon atoms; X is
<Chemistry id="chema02" num="0002"><Image id="ia02" he="7" wi="18" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>(R<Sub>5</Sub> is hydrogen or hydroxy) and n is 1-4; and their non-toxic pharmaceutically acceptable acid addition salts. These compounds exhibitvaluable pharmacological activity and are useful in the treatment of mammals, especially as anti- hypertensive agents. Furthermore, some of the compounds have proved to possess diuretic, ß-blocking activity and/or antithrombotic activity. The compounds may be made by a variety of methods and may be incorporated in pharmaceutical compositions also comprising a compatible pharmaceutically acceptable carrier.</p> |