| 摘要 |
Epoxysuccinic acid derivs. (I; R3 = -O-A1-R4, -O-A2-R5 or -OCH2-R6; A1 = C0-4 alkylene or methyl substituted C0-4 alkylene; R4 = C3-10 cycloalkyl, 1-3 halogen or Me substituted C3-10 cycloalkyl or C5-8 cycloalkenyl; A2 = C2-3 alkylene or C2-3 alkenylene; R5 = Ph; R6 = furyl, tetrahydrofuryl, thienylanphtyl or halogen substituted ph, Me or trifluoromethyl; R16 = H or alkali metal cation) were manufd. by hydrolysis of II partially. I had a papain inhibiting at 100 mg/kg orally in rats caused 82.1 % inhibition of adjuvant orthritis.
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