发明名称 |
Alkoxy-pyridyl substituted alkanes |
摘要 |
The compounds are C2-C8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N''-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis-[N'-(2-(3-methoxy-2-pyridylmethylthio)ethyl)guanidino]propane and 1-[N-(2-(3-methoxy-pyridylmethylthio)ethyl)guanidino]-3-[N'-2-(5-methy l-4-imidazolylmethylthio)ethyl) guanidino)propane. The compounds of this invention are inhibitors of H-2 histamine receptors.
|
申请公布号 |
US4282224(A) |
申请公布日期 |
1981.08.04 |
申请号 |
US19800112486 |
申请日期 |
1980.01.16 |
申请人 |
SMITH KLINE & FRENCH LABORATORIES LIMITED |
发明人 |
DURANT, GRAHAM J.;GANELLIN, CHARON R.;SACH, GEORGE S. |
分类号 |
C07D213/32;A61K31/44;A61K31/4402;A61K31/4418;A61K31/4427;A61K31/495;A61K31/50;A61K31/505;A61P43/00;C07D213/61;C07D213/65;C07D213/68;C07D213/69;C07D213/74;C07D401/12;C07D413/12;C07D417/12;C07D491/056;(IPC1-7):C07D401/12;A61K31/49 |
主分类号 |
C07D213/32 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|