PHARMACOLOGICALLY ACTIVE SUBSTITUTED 3-AMINO-SYDNONE-IMINES PROCESSES FOR THEIR PREPARATION AND THEIR USE

摘要

Physiologically-acceptable 3-aminosydnonimines of the formula (I) and their pharmacologically-acceptable acid-addition salts, when formulated into medicament dosage forms, are useful for reducing systemic blood pressure, pulmonary artery pressure and left ventricular end diastolic pressure when orally administered to patients in need of such pressure reduction. These compounds are prepared by cyclizing a compound which, in its free-base state, is of the formula (II) to a corresponding product which, in its free-base state, is of the formula (Ia) and, when R2 is other than -H, acylating that product.