| 摘要 |
<p>An intermediate compound useful in the preparation of bridged vinca dimers is described of the formula R<6>-NH-CH2-(CH2)n-Q min -(CH2)n-CH2-NH2 (III) wherein R<6> is an indole-dihydroindole part structure of the formula <CHEM> wherein R<2> is CH3 or H; when taken singly, one of R<3> and R<4> is OH or H and the other is C2H5 and R<5> is H; and when taken together R<1> and R<5> form an alpha -epoxide ring and R<3> is C2H5; and Q min is S, S-S, O, Se-Se, or (CH2)p wherein each n and p is 0, 1, 2,3 or 4.</p> |
