| 摘要 |
<p>Cpds. of formula Ar-A-Nr2-Ar'-CH(CF3)-Z-CHR1-COX (I) and their salts are new (where Ar is phenyl opt. substd. by 1-3 gps. selected from halogen, lower alkyl, lower alkoxy, CF3 and alkylenedioxy; A is a direct bond or 1-4C alkylene; Ar' is phenylene; Z is O or S; R1 is 1-5C alkyl; R2 is H or lower alkyl; X is OH, OM (where M is a cation), lower alkoxy, hydroxyalkoxy, polyhydroxyalkoxy, mono- or dialkylaminoalkoxy, NH2, mono- or dialkylamino, alkyleneamino, aralkylamino, alkyl(aralkyl)amino, NHOH, alkoxyamino, acyloxyamino or R3-1-piperazinyl, where R3 is lower alkyl, hydroxyalkyl, alkoxyalkyl or acyloxyalkyl). (I) may be prepd. by reacting Ar-A-N(R2)Ar'-C(ZH)H-CF3 with (R1)CHYCOX. (where Y is Cl, Br or I and X' is OH or alkoxy). The products can be converted to other cpds. (I) by standard methods. (I) are hypolipaemic agents giving reduced blood cholesterol and triglyceride levels, e.g. at doses of 0.5- 25 mg/kg (p.o.).</p> |
