DERIVATIVES OF 9-FLUOROPREDNISOLONE

摘要

Derivatives of 9-fluoroprednisolone which hav? only weak systemic action but when administered topically have a strong anti-inflammatory action. The compounds have the formula wherein R1 represents a group of the general formula RCO- in which R represents a hydrogen atom or an alkyl group or a cycloalkyl or cycloalkylalkyl group or an alkyl-substituted cycloalkyl or cycloalkylalkyl group, and R1 has from 1 to 8 carbon atoms, or in which R represents an aryl or aralkyl group or an alkylsubstituted aryl or aralkyl group, and R1 has up to 9 carbon atoms, and X represents a fluorine or chlorine atom or a group of the general formula R'COO- which has from 3 to 8 carbon atoms and in which R' represents an alkyl group or a cycloalkyl or cycloalkylalkyl group or an alkyl-substituted cycloalkyl or cycloalkylalkyl group.